IBSG Webinar Tháng 4-2024: Vascular endothelial cell engineering

Kính mời quý độc giả tham dự buổi Webinar tháng 4-2024 do Nhóm Học Thuật Y Sinh IBSG tổ chức trực tuyến qua Zoom.

Trong buổi webinar chuyên đề này, IBSG hân hạnh được sự tham gia của:

Duc-Huy Nguyen, PhD: postdoctoral associate, Department of Medicine, Weill Cornell Medical College

Chủ đề: Vasculogenesis and vascular endothelial cell engineering

Thông tin chi tiết về diễn giả xin mời quý độc giả xem tại đây:

Profile: https://directory.weill.cornell.edu/person/profile/dtn2002

Dr. Duc-Huy Nguyen holds an appointment as a Postdoctoral Associate in Dr. Robert Schwartz’s laboratory at Weill Cornell Medical College. Prior to his postdoctoral position in Dr. Robert Schwartz’s laboratory, Dr. Nguyen studied Chemical and Biomolecular Engineering at the California Institute of Technology. Subsequently, he completed his Ph.D. in Chemical and Biomolecular Engineering under the supervision of Dr. Christopher Chen at the University of Pennsylvania, where he innovated 3D biomimetic models to investigate angiogenesis and pancreatic tumor cell invasion. Following his Ph.D. training, he joined Dr. Shahin Rafii’s laboratory at Weill Cornell Medical College to investigate the molecular mechanism and transcriptional regulation of vascular endothelial cells during blood vessel formation. In Dr. Rafii’s lab, he engineered adult vascular endothelial cells with transcriptional programming to empower them with a robust capacity to vascularize organs and tissues. Currently, his research interests in Dr. Robert Schwartz’s laboratory range from stem cell research, to engineering biomimetic vascularized human liver models to investigate the physiology and pathology of the liver and liver tissue engineering.

Google Scholar: https://scholar.google.com/citations?hl=en&user=IwCkb-8AAAAJ&view_op=list_works&sortby=pubdate

Talk abstract:

The vasculature plays a critical role during embryogenesis and continues to regulate many essential biological processes of organs after birth. It delivers nutrients and gases to maintain tissue survival, transports biological wastes to appropriate organs for further processing, and enables the trafficking of immune cells to injured tissues. In tumors, the maladaptive vasculature invades the tumor tissues to fuel tumor growth and metastasis. Therefore, it is imperative to engineer biomimetic vascular models to investigate the multifaceted functions of the vasculature. In this talk, I will first discuss my work on engineering 3D biomimetic blood vessels to investigate the fundamental processes of blood vessel formation and utilize the biomimetic blood vessels to model the tumor-blood vessel interactions during pancreatic cancer invasion.
Recent advances in vascular biology reveal the crucial roles of endothelial cells (ECs) in supplying organ-specific cues to maintain organ functions in homeostasis. Consequently, adult ECs have been used to vascularize engineered organs and tissues to better mimic the biology of the organs. However, adult ECs lose their intrinsic ability in vitro to generate robust blood vessel networks and to interact and adapt to different cell types in co-culture, making them challenging to use in tissue engineering and translational applications.
To address this challenge, I will present my work on engineering adult ECs with transcriptional programming to empower adult ECs with a robust ability to form vascular networks and interact with other cells in co-culture. To demonstrate the utilities of the engineered adult ECs, I will also discuss my work on engineering a vascularized human liver model where the engineered ECs vascularize the liver tissue in microfluidic devices and support the function of primary human hepatocytes. Additional organs such as colon, pancreas, and bone marrow are also successfully vascularized in microfluidic devices by the engineered ECs.

Host: Nguyễn Bích Nụ

Thời gian: 8:00 – 9:00 sáng Chủ Nhật giờ Việt Nam, ngày 28.4.2024.

Zoom Meeting: 

https://uwmadison.zoom.us/j/95520371271?pwd=dmQ2VWFUREhYNmQwdUVHU2RiSGV5dz09

Meeting ID: 955 2037 1271

Passcode: IBSGW2024