IBSG Webinar March 2023: Molecular mechanism underlying interferon signaling regulation of myeloid differentiation

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IBSG is delighted to have Dr. Duy T. Le sharing with us his outstanding research on the molecular mechanism of Interferon signaling in hematopoiesis in our IBSG monthly webinar this March.


Duy Tri Le, PhD: Scientist I, Immatics US, USA

Title of the talk: BATF2 promotes HSC myeloid differentiation by amplifying IFN response mediators during chronic infection

The talk will focus on the story originated from Dr. Le’s PhD thesis at Baylor College of Medicine, Houston, TX.

Dr. Le has been co-first-authored or co-authored on many publications throughout his lab assistantship and graduate career.

Publications with co-first-authorship:

  • Duy T. Le*, Tridu R. Huynh*, Bryan Burt, George Van Buren, Shawn A. Abeynaike, Cristina Zalfa, Rana Nikzad, Farrah Kharadmand, John J. Tyner, and Silke Paust. Natural killer cells and cytotoxic T lymphocytes are required to clear solid tumor in a patient-derived xenograft. JCI Insight. June 3, 2021. *co-first authors
  • Daniel Hormaechea-Agulla*, Duy T. Le*, and Katherine Y. King. Common sources of inflammation and their impact on hematopoietic stem cell biology. Current Stem Cell Reports. August 19, 2020. *co-first authors

Publications with co-authorship as a collaborator:

  • Ruzhica Bogeska, Ana-Matea Mikecin, Paul Kaschutnig, Malak Fawaz, Marleen Büchler-Schäff, Duy T. Le, Miguel Ganuza, Angelika Vollmer, Stella V. Paffenholz, Noboru Asada, Esther Rodriguez-Correa, Felix Frauhammer, Florian Buettner, Melanie Ball, Julia Knoch, Sina Stäble, Dagmar Walter, Amelie Petri, Martha J. Carreño-Gonzalez, Vinona Wagner, Benedikt Brors, Simon Haas, Daniel B. Lipka, Marieke A.G. Essers, Vivienn Weru, Tim Holland-Letz, Jan-Philipp Mallm, Karsten Rippe, Stephan Krämer, Matthias Schlesner, Shannon McKinney Freeman, Maria Carolina Florian, Katherine Y. King, Paul S. Frenette, Michael A. Rieger, Michael D. Milsom. Inflammatory exposure drives long-lived impairment of hematopoietic stem cell self-renewal activity and accelerated aging. Cell Stem Cell. July 19, 2022.
  • Daniel E Morales-Mantilla, Bailee Kain, Duy T. Le, Anthony R Flores, Silke Paust, Katherine Y King. Hematopoietic stem and progenitor cells improve survival from sepsis by boosting immunomodulatory cells. eLife. February 15, 2022.
  • Daniel Hormaechea-Agulla*, Katie A. Matatall*, Duy T. Le, Bailee Kain, Xiaochen Long, Pawel Kus, Roman Jaksik, Grant Challen, Marek Kimmel, and Katherine Y. King. IFNg signaling is a driver of Dnmt3a-loss of function clonal hematopoiesis. Cell Stem Cell. March 19, 2021
  • Lynn Bimler, Sydney L. Ronzulli, Amber Y Song, Scott K Johnson, Cheryl A Jones, Teha Kim, Duy T. Le, S Mark Tompkins, and Silke Paust. Matrix Protein 2 Extracellular Domain-Specific Monoclonal Antibodies Are an Effective and Potentially Universal Treatment for Influenza A. Journal of Virology. December, 2020.
  • Lynn Bimler, Amber Y. Song, Duy T. Le, Ashleigh Murphy Schafer, and Silke Paust. AuNP-M2e+ sCpG vaccination of juvenile mice generates lifelong protective immunity to influenza A virus infection. Immunity & Ageing. September 2, 2019.
  • Rana Nikzad, Laura S. Angelo, Kevin Aviles-Padilla, Duy T. Le, Vipul K. Singh, Milica Vukmanovic-Stejic, Elena Vendrame, Thanmayi Ranganath, Laura Simpson, Lynn Bimler, Nancy L. Haigwood, Catherine A. Blish, Arne N. Akbar, and Silke Paust. Human natural killer cells mediate adaptive immunity to viral antigens. Science Immunology. May 10, 2019.
  • Frederic Van Gool, Michelle L.T. Nguyen, Maxwell R. Mumbach, Ansuman T. Satpathy, Wendy L. Rosenthal, Simone Giacometti, Duy T. Le, Weihong Liu, Todd M. Brusko, Mark. S. Anderson, Alexander Y. Rudensky, Alexander Marson, Howard Y. Chang, and Jeffrey A. Bluestone. A mutation in the transcription factor Foxp3 drives T helper 2 effector function in regulatory T cells. Immunity. February 19, 2019.
  • Eleonora Trotta, Paul H Bessette, Stephanie L Silveria, Lauren K Ely, Kevin M. Jude, Duy T Le, Charles R. Holst, Anthony Coyle, Mar Potempa, Lewis L. Lanier, Christopher Garcia, Natasha K. Crellin, Isaac J. Rondon, and Jeffrey A. Bluestone. A human anti-IL-2 antibodies that potentiate Regulatory T cells by a structure-based mechanism. Nature Medicine. July 24, 2018.
  • Emily M. Mace, Venetia Bigley, Justin T. Gunesch, Ivan Chinn, Laura S. Angelo, Michael D. Keller, Sumihito Togi, Levi B. Watkin, David F. LaRosa, Shalini N. Jhangiani, Donna M. Muzny, Asbjørg Stray-Pedersen, Zeynep Coban Akdemir, Jansen Smith, Duy T. Le, Graham Hogg, Tram Cao, Aharon G. Freud, Eva P. Szymanski, Sinisa Savic, Matthew Collin, Andrew J.
    Cant, Richard A. Gibbs, Steven M. Holland, Michael A. Caligiuri, Keiko Ozato, Silke Paust, Gina M. Doody, James R. Lupski, and Jordan S. Orange. Biallelic mutations in IRF8 impair human NK-cell maturation and function. The Journal of Clinical Investigation. November, 2016.

Host: Nguyễn Bích Nụ

Time: 9:00-10:00 AM Sunday Vietnam time, 19 March 2023.

Zoom Meeting: 


Meeting ID: 952 2909 1245

Passcode: IBSGW2023

Ý Kiến Độc Giả:

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