IBSG Webinar February 2023: Molecular Mechanism of Parkinson’s Disease

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IBSG is delighted to have Dr. Quyen Hoang sharing with us his outstanding research on the molecular mechanism of Parkinson’s disease in our IBSG monthly webinar this February.

Speaker:

Dr. Quyen Q. Hoang: Professor of Biochemistry and Molecular Biology, Indiana University School of Medicine.

Title of the talk: Molecular mechanism of Parkinson’s disease.

Some of the works published by Hoang Lab related to this topic:

Primary research articles:

  • Wu, C. X., Liao, J., Park, Y., Reed, X., Engel, V. A., Hoang, N. C., … & Hoang, Q. Q. (2019). Parkinson’s disease-associated mutations in the GTPase domain of LRRK2 impair its nucleotide-dependent conformational dynamics. Journal of Biological Chemistry294(15), 5907-5913.
  • Wang, W., Nguyen, L. T., Burlak, C., Chegini, F., Guo, F., Chataway, T., … & Hoang, Q. Q. (2016). Caspase-1 causes truncation and aggregation of the Parkinson’s disease-associated protein α-synuclein. Proceedings of the National Academy of Sciences113(34), 9587-9592.
  • Liao, J., Wu, C. X., Burlak, C., Zhang, S., Sahm, H., Wang, M., … & Hoang, Q. Q. (2014). Parkinson disease-associated mutation R1441H in LRRK2 prolongs the “active state” of its GTPase domain. Proceedings of the National Academy of Sciences111(11), 4055-4060.
  • Wang, W., Perovic, I., Chittuluru, J., Kaganovich, A., Nguyen, L. T., Liao, J., … & Hoang, Q. Q. (2011). A soluble α-synuclein construct forms a dynamic tetramer. Proceedings of the National Academy of Sciences108(43), 17797-17802.

Review articles:

  • Park, Y., Liao, J., & Hoang, Q. Q. (2022). Roc, the G-domain of the Parkinson’s disease-associated protein LRRK2. Trends in Biochemical Sciences.
  • Liao, J., & Hoang, Q. Q. (2018). Roco proteins and the Parkinson’s disease-associated LRRK2. International journal of molecular sciences19(12), 4074.
  • Park, Y., & Hoang, Q. Q. (2017). Combating Parkinson’s disease-associated toxicity by modulating proteostasis. Proceedings of the National Academy of Sciences114(5), 803-804.
  • Hoang, Q. Q. (2014). Pathway for Parkinson disease. Proceedings of the National Academy of Sciences111(7), 2402-2403.

To learn more about Dr. Hoang, please visit his Google Scholar page and his lab website.

Host: Nguyễn Bích Nụ

Time: 8:00-9:00 AM Sunday Vietnam time, 19 February 2023.

Zoom Meeting: 

https://uwmadison.zoom.us/j/96280881381?pwd=K3RXamtEbmZNNTBvOFF0UEdqT1Rodz09

Meeting ID: 962 8088 1381

Passcode: IBSGW2023

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