IBSG Webinar February 2023: Molecular Mechanism of Parkinson’s Disease

IBSG is delighted to have Dr. Quyen Hoang sharing with us his outstanding research on the molecular mechanism of Parkinson’s disease in our IBSG monthly webinar this February.

Speaker:

Dr. Quyen Q. Hoang: Professor of Biochemistry and Molecular Biology, Indiana University School of Medicine.

Title of the talk: Molecular mechanism of Parkinson’s disease.

Some of the works published by Hoang Lab related to this topic:

Primary research articles:

• Wu, C. X., Liao, J., Park, Y., Reed, X., Engel, V. A., Hoang, N. C., … & Hoang, Q. Q. (2019). Parkinson’s disease-associated mutations in the GTPase domain of LRRK2 impair its nucleotide-dependent conformational dynamics. Journal of Biological Chemistry, 294(15), 5907-5913.
• Wang, W., Nguyen, L. T., Burlak, C., Chegini, F., Guo, F., Chataway, T., … & Hoang, Q. Q. (2016). Caspase-1 causes truncation and aggregation of the Parkinson’s disease-associated protein α-synuclein. Proceedings of the National Academy of Sciences, 113(34), 9587-9592.
• Liao, J., Wu, C. X., Burlak, C., Zhang, S., Sahm, H., Wang, M., … & Hoang, Q. Q. (2014). Parkinson disease-associated mutation R1441H in LRRK2 prolongs the “active state” of its GTPase domain. Proceedings of the National Academy of Sciences, 111(11), 4055-4060.
• Wang, W., Perovic, I., Chittuluru, J., Kaganovich, A., Nguyen, L. T., Liao, J., … & Hoang, Q. Q. (2011). A soluble α-synuclein construct forms a dynamic tetramer. Proceedings of the National Academy of Sciences, 108(43), 17797-17802.

Review articles:

• Park, Y., Liao, J., & Hoang, Q. Q. (2022). Roc, the G-domain of the Parkinson’s disease-associated protein LRRK2. Trends in Biochemical Sciences.
• Liao, J., & Hoang, Q. Q. (2018). Roco proteins and the Parkinson’s disease-associated LRRK2. International journal of molecular sciences, 19(12), 4074.
• Park, Y., & Hoang, Q. Q. (2017). Combating Parkinson’s disease-associated toxicity by modulating proteostasis. Proceedings of the National Academy of Sciences, 114(5), 803-804.
• Hoang, Q. Q. (2014). Pathway for Parkinson disease. Proceedings of the National Academy of Sciences, 111(7), 2402-2403.

To learn more about Dr. Hoang, please visit his Google Scholar page and his lab website.

Host: Nguyễn Bích Nụ

Time: 8:00-9:00 AM Sunday Vietnam time, 19 February 2023.

Zoom Meeting: 

https://uwmadison.zoom.us/j/96280881381?pwd=K3RXamtEbmZNNTBvOFF0UEdqT1Rodz09

Meeting ID: 962 8088 1381

Passcode: IBSGW2023