IBSG Webinar 09-2021: Breast Cancer Epigenome Regulation

Kính mời quý độc giả tham dự buổi Webinar tháng 09-2021 do Nhóm Học Thuật Y Sinh IBSG tổ chức trực tuyến qua Zoom.

Trong buổi webinar chuyên đề này, IBSG hân hạnh được sự tham gia của:

T.s. Lưu Phúc Lợi: Garvan Institute of Medical Research.

Chủ đề: Dissecting breast cancer epigenome regulation on transcription and clinical application.

Host: Nguyễn Bích Nụ

Abstract:

Gene promoter hypomethylation in some human cancers compared to their normal counterparts is discovered nearly 40 years ago. This loss of DNA methylation at promoter CpG dinucleotides is the first epigenetic abnormality to be identified in cancer cells. The hypomethylation of DNA can lead to transcription activation and mostly occur in oncogenes. In contradiction, a gain of methylation at the promoters of some tumor suppressor genes in a range of tumor types is also observed and initialize the gene deactivation. In short, DNA methylation regulates gene expression in tumor progression, but this is not the whole picture. The advancing of technology in next-generation sequencing and bio-molecular assays in recent years helps to reveal the leftover. In this first part of the presentation, I would like to describe the paradoxical role of DNA methylation in transcription modulation with other epigenetic marks of breast cancer to fully understand the underline mechanism. In the second part, I will focus on the work-flow of the development of DNA methylation as a biomarker for clinical diagnosis. First, I will show DNA methylation is a promising biomarker for early detection of breast cancer, then applying these markers on public genome-wide methylomes for computational prediction. Finally, the passed markers are validated in primary tissue/FFPE or solid biopsy and circulating cell-free DNA (ccfDNA) or liquid biopsy.

Thời gian: 9:00 – 10:00 AM Chủ Nhật giờ Việt Nam (tương ứng với 7:00 – 8:00 PM thứ Bảy theo giờ California), ngày 12.09.2021.

Tham dự trực tuyến qua Zoom tại: https://uwmadison.zoom.us/j/96593824750

Meeting ID: 965 9382 4750

Lệ phí tham dự: hoàn toàn miễn phí

Lưu ý: Khách tham dự không ghi âm, quay clip, và chụp hình khi chưa có sự đồng ý của diễn giả (ban tổ chức sẽ phụ trách việc này).