Tuyển sinh post-doctoral tại Uppsala University

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Giáo sư Mikael Sellin tại SciLifeLab, Uppsala University, đang tìm kiếm một PhD cho vị trí post-doctoral trong nhóm nghiên cứu của giáo sư. Ứng cử viên tiềm năng có nền tảng tốt về mammalian cell biology/developmental biology.

Application deadline: August 12th 2018
Starting date: as soon as possible
Finances: fully supported (monthly salary) by SciLifeLab for a period of 24 months
Link to add and application portal: http://www.uu.se/en/about-uu/join-us/details/?positionId=215638

Project description:

The Sellin research group at IMBIM, Uppsala University, studies interactions between invasive enterobacteria, such as Salmonella andShigella species, and the mammalian intestinal epithelium (www.imbim.uu.se/research-groups/infections-and-defences/sellin-mikael). Current research in the group includes infection studies in miniature cultured versions of the mammalian intestine (so called organoids), which can be generated by embedding mouse or human intestinal stem cells in a rich 3D matrix. The post-doctoral fellow will have an active role in further developing this experimental infection model system. Specifically, the project involves i) devising protocols for targeted differentiation of organoids towards structures enriched in the major cell types of the mammalian gut (absorptive epithelial cells, mucus-producing goblet cells, antimicrobial peptide-producing paneth cells a.s.o.) and ii) using the experimental model systems to analyse how enterobacteria bind and/or invade these diverse cell types. The project relies on methods for cell line and primary tissue culture, mammalian and bacterial genetics, and high-resolution light microscopy combined with complementary readouts.

Để biết thêm thông tin, độc giả có thể liên lạc trực tiếp với Dr. Sellin qua email mikael.sellin@imbim.uu.se

Nguồn: Dr. Bùi Thị Thu Hiền

Nguồn hình cover: Uppsala University

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